Omics · study · 2026
Transcriptomic profiling of PHD2-deficient and control mc38 tumors with or without indole-3-pyruvic acid treatment
Listed in NCBI GEO
This study investigated the role of PHD2 (Egln1) in the transcriptional response of murine colorectal tumors to indole-3-pyruvic acid (IPyA). mc38 vector-control or Egln1/PHD2-deficient cells were used to establish subcutaneous tumors in C57BL/6J mice.
Description
Mice were assigned to untreated/control or IPyA-treated groups, and IPyA was administered intraperitoneally at 0.2 mg/kg every 2 days. Fifteen tumor samples were included in this GEO submission: Vec (n=3), Vec+IPyA (n=4), sgPHD2 (n=4), and sgPHD2+IPyA (n=4).
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE347nnn/GSE347540 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE347540 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1530462 ncbi.nlm.nih.gov/bioproject/PRJNA1530462 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE347540 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |