Transcriptomic of Visceral Adipose Tissue in HFD-induced obesity: evaluation of Resveratrol

This series examines the transcriptomic profile of VAT in male C57BL/6 mice subjected to long-term obesity induced by a high-fat diet (HFD, 60% of kcal from fat). To investigate new therapeutic avenues, we evaluated the impact of daily resveratrol administration (2.25 mg/kg) for 28 days, beginning at week 16 of life (8 weeks on the HFD diet).

Using a transcriptomic approach (RNA-seq), we mapped the expression changes associated with the transition from healthy to dysfunctional adipose tissue. This study provides a detailed molecular resource for understanding how obesity-induced adipocyte stress can be attenuated by natural bioactives.