Omics · study · 2026
N6-Methyladenosine-Modified circPICALM Encodes a Protein That Promotes Intrahepatic Cholangiocarcinoma Metastasis
Listed in NCBI GEO
Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive primary liver cancer characterized by rapid progression and strong metastatic potential.
Description
Circular RNAs (circRNAs) are emerging as crucial regulators in the complex biology of cancer, yet their specific roles in ICC metastasis remain poorly defined. In this study, circRNA sequencing of paired primary and recurrent ICC tissues revealed that elevated expression of circRNA PICALM (circPICALM) is strongly linked to ICC metastasis and patient prognosis.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE291nnn/GSE291554 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE291554 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1234138 ncbi.nlm.nih.gov/bioproject/PRJNA1234138 ↗
project · from NCBI GEO
- PubMed 41776633 pubmed.ncbi.nlm.nih.gov/41776633 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens · Non-coding RNA profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE291554 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:non-coding-rna-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |