Omics · study · 2026
Transcriptome regulation by miR-210 in hypoxic glomerular endothelium [RNA-seq]
Listed in NCBI GEO
Hypoxia occurs in both acute and chronic kidney diseases.
Description
Despite the central role of tubular injury in acute kidney injury (AKI), a hallmark feature is a reduction in glomerular filtration rate. There is now an increasing interest in the effect of direct injury to the renal vasculature and its potential role in the pathogenesis of AKI.
In this study, we profiled glomerular endothelial miRNA and mRNA changes in response to hypoxia in vitro. We identified significant induction of a hypoxia associated miRNA, miR-210-3p, which enhanced cellular glycolytic capacity. Furthermore, integrated transcriptomic analysis identified HIF1A and TFRC as putative miR-210-3p targets.
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This was corroborated by the strong correlation in glomerular endothelial TfR1 and HIF-1α protein expression in kidney tissue samples. Collectively, our study uncovered a compensatory mechanism in which miR-210-3p supports glomerular endothelial adaptation by modulating bioenergetics, thereby fine-tuning hypoxia responses and limiting cellular injury.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326398 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326398 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1445184 ncbi.nlm.nih.gov/bioproject/PRJNA1445184 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE326398 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |