Ozone exposure in the fibrotic Surfactant Protein-C mutant lung

We have established a murine model of lung remodeling triggered by inducible expression of the most common PF-linked mutation in the Surfactant Protein-C gene (SP-C). The mutation at position 73 is the most common among >60 clinically identified.

We have previously deposited a single-cell sequencing dataset of lung tissues at times coordinated with peak inflammation (14 d post induction) and established fibrotic remodeling (42 d post induction). This work allowed annotation of fibrogenic signals emanating from the epihtelial, mesenchymal, and immune compartment. We then set aim to expand our investigation to examine the effects of ozone exposure in the fibrotic lung (42 days post mutant induction).