Omics · study · 2026
PLC-IP3 signaling regulate sensory hair cell formation in zebrafish neuromast
Listed in NCBI GEO
Hearing loss typically arises from irreversible damage to sensory hair cells (HCs) in the inner ear.
Description
Currently, restoring the number and function of HCs in mammals remains a significant challenge, hindered by an inadequate understanding of the molecular mechanisms governing the differentiation of sensory HCs. Therefore, identifying novel regulators that promote supporting cell (SC) differentiation and HC formation is crucial in the field.
Phosphoinositide-specific phospholipase C (PLC) converts extracellular cues into IP3 and DAG to activate Ca²⁺/PKC signaling that drives cell-state transitions in proliferation, differentiation, and repair. However, the role of PLC in HCs differentiation has remained poorly defined in the context of HCs lineage progression and maturation. Here, we found that inhibiting PLC signaling reduces HC output from the progenitor pool, while activating the pathway enhances HC formation.
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Among PLC isoforms, plcd4a is selectively enriched in HCs and is required for HCs formation. Mechanistically, we demonstrate that these processes are mediated through the Notch/Wnt-PLC-IP3 signaling axis. These findings identify PLC–IP3 signaling as a regulatory node linking HC formation with maturation.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE319nnn/GSE319405 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319405 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1423239 ncbi.nlm.nih.gov/bioproject/PRJNA1423239 ↗
project · from NCBI GEO
Topics
- Stated by source
- Danio rerio · Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE319405 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:7955 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |