Omics · study · 2026
Regulation of gene expression by IL-12P40 heterodimers
Listed in NCBI GEO
The IL-12 family of cytokines are unique in that they are formed by heterodimerization of two proteins, encoded by distinct genetic loci.
Description
We previously reported that the shared subunit of IL-12 and IL-23, namely IL-12P40, can interact biochemically with other partners in vivo. The functional role of these potentially new heterodimeric immunomodulatory cytokines are not known.
Here we use hydrodynamic delivery of plasmids encoding four of the top binding partners we identified (CD5L, Resistin-like Gamma, Clusterin and Pentatraxin V) into IL-20-p40 deficient mice, in order to profile the changes in splenic cell gene expression.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE333nnn/GSE333171 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE333171 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1470260 ncbi.nlm.nih.gov/bioproject/PRJNA1470260 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE333171 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |