RNA-seq profiling of ileal tuft cells with tuft cell-specific HDAC3 deletion

To define transcriptional programs associated with histone deacetylase 3 (HDAC3) in tuft cells, we performed RNA sequencing on sort-purified tuft cells isolated from the ileum of mice with tuft cell-specific deletion of HDAC3 (HDAC3ΔTuft) and littermate control (HDAC3 floxed) mice. This dataset provides a resource for examining gene expression differences associated with HDAC3 loss in intestinal tuft cells.