Excel · study · 2026
Transcriptomic profiling of AC16 cardiomyocytes under TPEN-induced zinc deficiency
Listed in NCBI GEO
Zinc deficiency is an important risk factor for myocardial injury, yet the underlying cytoprotective mechanisms remain incompletely understood.
Description
In this study, bulk RNA sequencing was performed in human AC16 cardiomyocytes treated with the zinc chelator TPEN or vehicle control to characterize transcriptional changes induced by zinc deficiency. Differential expression and pathway enrichment analyses revealed activation of apoptosis- and stress-related pathways, providing a transcriptomic framework for subsequent mechanistic investigations of ATF3-mediated mitochondrial and survival signaling.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318912 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318912 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1420801 ncbi.nlm.nih.gov/bioproject/PRJNA1420801 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE318912 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |