Omics · study · 2026
DNMT1 Facilitates the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease [RNA-seq]
Listed in NCBI GEO
Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by notable epigenetic changes, such as alterations in DNA methylation.
Description
However, research on epigenetic modifications in human patient and animal models remains sparse. This study investigates the role of DNMT1 in MASLD progression.
DNMT1 inhibition restores DNA methylation patterns and transcriptional activity, suggesting it as a potential therapeutic target for MASLD.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE284nnn/GSE284446 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE284446 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1199025 ncbi.nlm.nih.gov/bioproject/PRJNA1199025 ↗
project · from NCBI GEO
- PubMed 41592598 pubmed.ncbi.nlm.nih.gov/41592598 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE284446 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |