Omics · study · 2026
Gene expression profiling of GLP1R-IL17A axis in obesity driven PTPN11-mutant leukemia
Listed in NCBI GEO
Obesity-associated metabolic inflammation contributes to the progression of PTPN11-mutant myeloid leukemia through activation of the IL-17A–mediated inflammatory axis and suppression of GLP-1R signaling.
Description
In this study, mRNA-seq was performed on hematopoietic and immune cell populations from a murine transplantation model of Shp2E76K/+ leukemia under obese conditions, with or without treatment using an anti-IL-17A antibody and a GLP-1R agonist.
Transcriptomic analysis reveals that obesity promotes leukemogenesis by enhancing myeloid expansion, lipid metabolic reprogramming, and immunosuppressive remodeling characterized by M2-like tumor-associated macrophage accumulation, T cell exhaustion, and impaired antigen presentation. Therapeutic targeting of the GLP-1R–IL-17A axis restores immune function, including Ciita-dependent antigen presentation and IFNγ signaling, and reduces leukemic burden.
Read the rest (1 more)
These data provide insight into the molecular mechanisms linking obesity-driven inflammation to leukemia progression and identify potential therapeutic targets.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327968 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327968 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1453410 ncbi.nlm.nih.gov/bioproject/PRJNA1453410 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE327968 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |