Omics · study · 2026
Overexpression of KLF4 in SSc lung fibroblasts initiates dedifferentiation
Listed in NCBI GEO
KLF4 was overexpressed by adenoviral infection in primary human SSc lung fibroblasts, RNA and protein were extracted, RNA sequencing and differential expression analysis "ad-KLF4 vs ad-Null" were performed to obtain gene and systems level analyses.
Description
Markers of alveolar, inflammatory and fibrotic fibroblasts were validated by qPCR and immunoblotting. Our results show that overexpression of KLF4 in SSc fibroblasts initiated dedifferentiation.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE317nnn/GSE317058 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE317058 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1405711 ncbi.nlm.nih.gov/bioproject/PRJNA1405711 ↗
project · from NCBI GEO
- PubMed 42193930 pubmed.ncbi.nlm.nih.gov/42193930 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE317058 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |