The mechanism of circular RNA circ0061693 and its encoded peptide P385 in improving neural injury in Parkinson's disease

Circular RNAs (circRNAs) are a unique class of stable closed-loop RNA molecules that exert biological functions via molecular sponging, transcriptional regulation, peptide translation, and other mechanisms. Accumulating studies have demonstrated that circRNAs are differentially expressed between PD patients and healthy controls; however, their precise mechanistic roles in PD pathogenesis remain incompletely understood.

Therefore, in-depth investigation of the functions and regulatory mechanisms of circRNAs in PD is critical for elucidating disease etiology and identifying novel diagnostic biomarkers and therapeutic targets.