Omics · study · 2026
3'RNA-seq profiling of eurycomanone-treated versus DMSO-treated resting immortalized rheumatoid arthritis fibroblast-like synoviocytes
Listed in NCBI GEO
Rheumatoid arthritis fibroblast-like synoviocytes (RAFLS) were treated with the CHIKV inhibitor eurycomanone or DMSO vehicle control for 6 h. 3'RNA-seq was performed on resting, uninfected cells because replication-competent CHIKV requires BSL-3 containment that was unavailable.
Description
Eurycomanone induced a coherent host transcriptional program characterized by activation of innate immune signaling and stress-response pathways, providing a resource for understanding host-directed antiviral mechanisms.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE346nnn/GSE346383 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE346383 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1525221 ncbi.nlm.nih.gov/bioproject/PRJNA1525221 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE346383 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |