Omics · study · 2026
hepatic transcriptional profile of diet-induced obese mice treated with rosuvastatin and GGOH
Listed in NCBI GEO
Atherosclerotic cardiovascular disease is the leading cause of death worldwide, and statins are the primary therapy for lowering LDL cholesterol and reducing cardiovascular risk.
Description
In addition to inhibiting cholesterol synthesis, statins reduce the production of geranylgeranyl isoprenoids, which regulate the activity of small GTPases such as Rap1a. To identify hepatic genes and pathways regulated by geranylgeranyl isoprenoids, we performed RNA sequencing of liver samples from mice treated with vehicle, statin, geranylgeraniol (GGOH), or statin plus GGOH.
This dataset was generated to identify transcriptional programs regulated by geranylgeranyl isoprenoids and to discover candidate genes involved in hepatic cholesterol metabolism and PCSK9 regulation.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE337nnn/GSE337548 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE337548 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1490388 ncbi.nlm.nih.gov/bioproject/PRJNA1490388 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cardiovascular disease 75% · Disease 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE337548 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cardiovascular-disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |