Omics · study · 2026
H2A.J is a driver of IL-17-associated inflammation in Th17 cells and keratinocytes [Th17 cells]
Listed in NCBI GEO
Psoriasis is a common autoinflammatory disease driven by excessive IL-17 expression.
Description
While the pathomechanism of the disease has been revealed, epigenetic factors contributing to psoriasis are less well understood. Here, we investigated the role of the rather unknown histone variant H2A.J in psoriasis.
We uncovered that H2A.J becomes overexpressed in the skin of psoriasis patients. Furthermore, global H2A.J KO mice are partially protected against experimentally induced psoriasis, shown by reduced immune cell infiltration and lower hyperkeratosis of the skin. This was likely due to the diminished expression of various chemokines and cytokines in the skin of psoriatic H2A.J KO mice, including CXCL1, CCL3, or IL-17A.
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Further analysis revealed that H2A.J regulated a subset of IL-17-responsive genes and differentiation markers in keratinocytes, thereby partially explaining the observed phenotype in the IMQ-treated H2A.J KO mice. Furthermore, we uncovered a T-cell intrinsic function of H2A.J, as it specifically mediated the expression of several effector molecules such as Il17a in TH17 cells, leading to reduced levels of functional TH17 cells in IMQ-treated H2A.J KO mice.
Thus, we identified H2A.J as a key epigenetic regulator of IL-17-associated inflammation, which controls the (chronic) activation of TH17 cells and keratinocytes in psoriasis.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE307nnn/GSE307885 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307885 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1327673 ncbi.nlm.nih.gov/bioproject/PRJNA1327673 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE307885 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |