Omics · study · 2026
Acute Hypoxia Alters Electrocardiology and Transcriptomics in Adult Zebrafish (Danio rerio)
Listed in NCBI GEO
We combined electrocardiography and transcriptomic profiling to investigate the short- and long-term effects of acute hypoxia on adult zebrafish hearts, testing the hypothesis that rapid recovery of cardiac function does not necessarily indicate concurrent recovery at the molecular level.
Description
Continuous ECG recordings revealed pronounced bradycardia during hypoxic exposure, characterized by reduced heart rate (f_H) and prolonged RR intervals.
Upon reoxygenation, f_Hincreased and RR intervals shortened within 2–5 minutes as oxygen levels normalized, anesthesia was discontinued, and β-adrenergic stimulation (isoproterenol) restored cardiac excitability. Despite this swift physiological recovery, transcriptomic analyses conducted seven days post-hypoxic exposure demonstrated persistent differential gene expression in previously hypoxia-affected fish compared with sham controls.
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Upregulated genes were associated with stress response and structural stabilization, whereas downregulated genes suggested a metabolic shift toward energy conservation. Together, these findings indicate a subdued transcriptional landscape consistent with cellular stabilization rather than ongoing injury. In summary, while ECG data alone might imply that acute hypoxic effects are transient, transcriptomic evidence reveals a sustained molecular imprint of hypoxic stress in the zebrafish heart that persists well beyond apparent functional recovery.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE319nnn/GSE319817 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319817 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1425136 ncbi.nlm.nih.gov/bioproject/PRJNA1425136 ↗
project · from NCBI GEO
- PubMed 42466388 pubmed.ncbi.nlm.nih.gov/42466388 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Danio rerio · Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- Heart 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE319817 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[anatomy].local:anatomy:heart | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:7955 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |