Omics · study · 2026
Faecalibacterium prausnitzii induces an anti-inflammatory response and a metabolic reprogramming in human monocytes [ileum]
Listed in NCBI GEO
We isolated immune cells from human intestinal lamina propria of patients with IBD and non-inflamed controls.
Description
We stimulated them with F. prausnitzii EXL01 strain, Cadaverine or lipopolysaccharide (LPS) from Escherichia coli and performed RNA-sequencing analysis. F. prausnitzii EXL01 strain induced the production of IL-10 in CD14+ monocytes from intestinal tissue of IBD patients and non-inflamed controls in a direct and dose-dependent manner, without inducing a pro-inflammatory response as compared to LPS stimulation.
RNAseq analysis confirmed these results and revealed that F. prausnitzii EXL01 strain differentially affects cell energy metabolism compared to LPS. The anti-inflammatory response induced by F. prausnitzii in monocytes was dependent on mitochondrial activity. In patients with inflammatory bowel disease (IBD), increased cadaverine levels were associated with higher flare risk.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE285nnn/GSE285449 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE285449 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1203649 ncbi.nlm.nih.gov/bioproject/PRJNA1203649 ↗
project · from NCBI GEO
- PubMed 41553310 pubmed.ncbi.nlm.nih.gov/41553310 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE285449 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |