Omics · study · 2026
The transcriptional cofactor Tle3 programs resident memory CD8+T cells differentiation [ChIP-seq]
Listed in NCBI GEO
Tissue-resident CD8+ T cells (CD8+ TRM) possess the ability to efficiently eliminate invading pathogens locally and are an essential component of the immune barrier.
Description
The upregulation of tissue residency-related genes and the downregulation of tissue egress-related genes are critical for the differentiation and long-term residency of CD8+ TRM. However, the coordinated regulatory mechanisms of these two transcriptional programs remain unclear.
Tle3 is a transcriptional cofactor that promotes and maintains the differentiation of circulating memory CD8+ T cell subsets by cooperating with key transcription factors. However, its role in the differentiation of CD8+ TRM remains unknown. Our preliminary studies indicate that Tle3 promotes the differentiation of CD8+ TRM subsets in multiple tissues, including the lung, and serves as a key regulator of TRM differentiation.
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Transcriptomic analysis suggests that Tle3 regulates CD8+ TRM differentiation by promoting the expression of TRM-associated genes while suppressing tissue egress-related genes, highlighting its crucial role in establishing the transcriptional program of CD8+ TRM and balancing the expression of residency and egress-related genes. Nevertheless, the key downstream molecules regulated by Tle3 and how it coordinates different transcriptional networks remain unclear.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326374 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326374 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1445168 ncbi.nlm.nih.gov/bioproject/PRJNA1445168 ↗
project · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE326374 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |