Omics · study · 2026
Borrelia burgdorferi induces durable tolerogenic reprogramming in bone marrow cells
Listed in NCBI GEO
Borrelia burgdorferi (Bb), the causative agent of Lyme disease, is known for its remarkable ability to persist within mammalian hosts.
Description
The dynamic host-pathogen interaction induces acute inflammation as well as lasting changes in host immunity. Here, we show that Bb infection leads to persistent transcriptional reprogramming in the bone marrow, the site of hematopoiesis.
This unique response is characterized by early induction of interferon-stimulated genes accompanied by sustained suppression of other classical proinflammatory pathways throughout infection. Functionally, bone marrow-derived macrophages (BMDMs) from Bb infected mice exhibit a significant reduction in proinflammatory cytokine production upon secondary ex vivo Bb stimulation, suggesting a tolerogenic imprinting of the myeloid lineage.
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We show that this tolerogenic state is rooted in a remodeled chromatin landscape of those macrophages, characterized by reduced accessibility of proinflammatory transcription factor motifs. Interestingly, this dampened pro-inflammatory response persists for at least 15 weeks post Bb infection and is partially maintained even after pathogen clearance by antibiotic treatment, despite restoration of certain proinflammatory transcripts in the bone marrow.
Our findings reveal a prolonged form of innate immune tolerance imprinted by Bb infection, with potential implications for post-infectious immune function in Lyme disease.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE314nnn/GSE314798 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE314798 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1392615 ncbi.nlm.nih.gov/bioproject/PRJNA1392615 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Genome binding/occupancy profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE314798 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |