Excel · study · 2026
Analysis of gene expression profiles in matched cancer-associated and non-tumoral fibroblasts from patients with head and neck squamous cell carcinoma
Listed in NCBI GEO
Among stromal components, cancer-associated fibroblasts (CAFs) constitute the predominant non-malignant population in the HNSCC microenvironment, where their abundance correlates with advanced disease and poor prognosis.
Description
CAFs support tumor progression via extracellular matrix remodeling and paracrine signaling through cytokines, growth factors, exosomes and miRNA. Here, we carried out a transcriptomic analysis of 6 couples of CAFs and matching non-tumoral fibroblasts (NFs) derived from HNSCC patients in order to reveal gene expression changes between CAF and NF cell populations and identify potential CAF-specific therapeutic targets.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE303nnn/GSE303690 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE303690 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1297100 ncbi.nlm.nih.gov/bioproject/PRJNA1297100 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE303690 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |