Omics · study · 2026
Clip2 as a novel regulator of osteocyte maturation and morphology
Listed in NCBI GEO
The genes driving osteocyte maturation and function are not fully understood.
Description
We identified CD61 (integrin beta-3) as a marker of osteocyte maturation and developed a flow cytometry-based assay to quantify surface CD61 protein levels. Surface CD61 expression increases during osteocyte maturation, and CD61-high cells express higher levels of osteocyte marker genes.
In a genome-wide screen, we identified Clip2, which encodes a microtubule binding protein, as one of dozens of genes necessary for CD61 expression.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE311nnn/GSE311295 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE311295 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1368893 ncbi.nlm.nih.gov/bioproject/PRJNA1368893 ↗
project · from NCBI GEO
- PubMed 42055327 pubmed.ncbi.nlm.nih.gov/42055327 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE311295 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |