Data · study · 2026
Tamoxifen Targets Wisp2 to Impair Subcutaneous Adipose Progenitor Self-Renewal and Adipogenic Differentiation
Listed in NCBI GEO
Prolonged tamoxifen treatment for estrogen receptor positive breast cancer disrupts estrogen receptor signaling in subcutaneous adipocytes and downregulates Wnt1-inducible signaling pathway protein 2 (Wisp2/Ccn5), a key regulator of progenitor cell maintenance.
Description
The resulting reduction in cell proliferation, impaired self renewal of progenitors, and reduced adipogenic differentiation by tamoxifen prevents healthy adipose tissue expansion.
This study reveals a molecular mechanism for the effects of tamoxifen on adipocyte precursors. To evaluate and compare changes in gene expression profiles, we performed global transcriptomic and pathway analyses following treatment of cells with estradiol or 4OH-tamoxifen, or in cells with or without Wisp2.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318553 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318553 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1419219 ncbi.nlm.nih.gov/bioproject/PRJNA1419219 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by array · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE318553 | 7 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |