Omics · study · 2026
TCF3 cooperates with CXXC1 to regulate histone H3K4 trimethylation and developmental competence in mouse oocytes
Listed in NCBI GEO
Oocyte meiotic maturation is essential for female gamete development and maternal-zygotic transition (MZT).
Description
In this study, we demonstrate that transcription factor 3 (TCF3) is a key maternal factor for oocyte development and maturation. Oocyte-specific knockdown of Tcf3 leads to abnormal meiotic maturation of oocytes, resulting in infertility of Tcf3oo-/- mice.
These mice exhibit impaired oocyte spindle assembly, accompanied by maternal mRNA degradation and reduced H3K4 trimethylation levels. Moreover, we reveal that TCF3 and CXXC1 form a complex on DNA to maintain H3K4me3 accumulation, which is required for embryonic development. Maternal knockdown of TCF3 disrupts H3K4me3 establishment, causing embryonic arrest at the 2-cell stage.
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Therefore, our study elucidates a critical mechanism by which TCF3 regulates oocyte developmental progression.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE305nnn/GSE305326 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE305326 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1305324 ncbi.nlm.nih.gov/bioproject/PRJNA1305324 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Genome binding/occupancy profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE305326 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |