Omics · study · 2026
Intestinal intraepithelial lymphocyte migration and tissue homeostasis are dictated by Ga13
Listed in NCBI GEO
The intestinal barrier harbors numerous intraepithelial lymphocytes (IEL) that promote tissue integrity and whose dysfunction contributes to disease.
Description
The signals regulating IEL dynamics are incompletely understood. Here we show that deficiency in heterotrimeric G-protein subunit Ga13 or effector Arhgef1 causes a loss of CD8aa and CD8ab IEL.
Following Ga13 ablation, IEL reduce migration speed prior to undergoing cell death. Induction of CD8ab IEL by Listeria monocytogenes is intact but the cells fail to distribute along the villi and quickly die. TGFb gain-of-function rescues Arhgef1-deficient CD8ab cell numbers.
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CRISPR screening identifies a role for Ga13-coupled GPR132 in IEL homeostasis. T cell Ga13-deficient mice suffer more severe colitis and colorectal tumor growth. In summary, we identify Ga13 as an essential signaling node in ab and gd CD8 IEL and we propose Ga13-guided IEL positioning in the villous niche is required for receipt of signals, including TGFb, for their maturation, survival and function.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE321nnn/GSE321684 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE321684 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1429293 ncbi.nlm.nih.gov/bioproject/PRJNA1429293 ↗
project · from NCBI GEO
- PubMed 42607677 pubmed.ncbi.nlm.nih.gov/42607677 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus · Other
- From keywords
- Life Sciences
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE321684 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |