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Omics · study · 2026

Modulating MyoD1 dosage activates alternate cell fate beyond myogenic differentiation [ATAC-seq]

Listed in NCBI GEO

The study investigates how MyoD1 dosage controls myogenic cell fate, employing bulk RNA-seq, ATAC-seq, and CUT&RUN.

Description

We determined genome-wide transcriptional, chromatin accessibility, and MyoD1 binding profiles in C2C12 myoblasts expressing endogenous Halo-tagged MyoD1 or doxycycline-inducible Halo–MyoD1, under growth and differentiation conditions with low or high MyoD1 dosage.

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Genome binding/occupancy profiling by high throughput sequencing · Mus musculus
From keywords
Life Sciences
Inferred from text
RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE30986414 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[modality].local:modality:rna-seqenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (65%)
concepts[organism].NCBITaxon:10090source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title