Omics · study · 2026
Spatial transcriptomics of early-grade Huntington’s disease and control Caudate
Listed in NCBI GEO
The molecular mechanisms that underlie striatal subregional and cell subtype-specific vulnerabilities and the cascade of molecular events occurring during Huntington’s disease remain poorly defined.
Description
Visium HD spatial transcriptomics was applied in early-grade Huntington’s disease Caudate and a pathologically-normal control. These data validate findings of cell type diversity (i.e. cholinergic and striosomal specialization), and define Huntington’s disease-associated changes in cell abundance, gene expression, and MSN de-repression.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE337nnn/GSE337131 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE337131 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1484112 ncbi.nlm.nih.gov/bioproject/PRJNA1484112 ↗
project · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Other
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE337131 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |