Modulation of tumor-derived exosomes and reprogramming of cancer-associated fibroblasts for colorectal cancer therapy

This hypothesis is supported by multiple machine learning algorithms, clinical data, molecular and genomic analyses, functional status profiling, drug response evaluation, trajectory inference, and cell–cell communication studies using bulk multi-omics and single-cell datasets (pan-cancer with ICB therapy or without therapy information, along with in-house CRC scRNA data (CRC_multi_omics.zip), culminating in in vitro/in vivo experimental validation.