Data · study · 2026
Cohesin loading at regulatory elements shapes 3D genome folding during erythropoiesis
Listed in NCBI GEO
During erythropoiesis, differentiating cells silence much of the genome while maintaining high expression of select genes.
Description
It remains unclear whether this transcriptional specialization is linked to specific changes in 3D genome organization. We generated deep Micro-C maps across human erythropoiesis to understand the relationship between cis-regulatory elements and cohesin-mediated loop extrusion during erythroid differentiation.
Shifts in erythroid 3D genome structure during differentiation and under perturbations of transcription factors and cohesin subunits/cofactors indicates that a subset of CREs concentrate loop extrusion near key genes during erythroid differentiation.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE341nnn/GSE341414 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE341414 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1502593 ncbi.nlm.nih.gov/bioproject/PRJNA1502593 ↗
project · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Other
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE341414 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |