Omics · study · 2026
Thyroid Hormone Activation Drives Fibroblast Identity and Tumor Remodeling in Cutaneous Squamous Cell Carcinoma
Listed in NCBI GEO
Cutaneous squamous cell carcinoma (cSCC) is a major cause of cancer-related mortality, with Cancer-Associated Fibroblasts (CAFs) acting as central drivers of tumor progression and immunotherapy resistance.
Description
We identified Type 2 deiodinase (D2)-mediated thyroid hormone signaling as a critical regulator of CAF activation. To elucidate the molecular mechanisms governing this reprogramming, we performed RNA-sequencing on CAFs isolated from fibroblast-specific D2 knockout (Col1a2-Cre; D2fl/fl) and wild-type mice (Col1a2-Cre; D2wt/wt).
Furthermore, we assessed transcriptional rescue by treating D2-deficient CAFs with exogenous T3. This dataset defines the D2-dependent gene signatures associated with metabolic remodeling and collagen-rich matrix deposition, identifying thyroid hormone signaling as a driver of fibroblast heterogeneity and a potential therapeutic vulnerability in cSCC.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318836 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318836 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1420710 ncbi.nlm.nih.gov/bioproject/PRJNA1420710 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE318836 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |