Omics · study · 2026
KLF2-dependent chromatin accessibility changes in hepatic stellate cells
Listed in NCBI GEO
Krüppel-like factor 2 (KLF2) is a transcription factor involved in regulating cellular homeostasis and diverse signaling responses.
Description
To investigate KLF2-associated changes in chromatin accessibility in human hepatic stellate cells, we performed ATAC-seq on LX-2 cells stably expressing KLF2 or control vector. Genome-wide chromatin accessibility profiles were compared between the two groups to identify KLF2-dependent changes.
This dataset provides a resource for exploring the potential epigenomic mechanisms underlying KLF2-mediated regulation of hepatic stellate cell function.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE343nnn/GSE343805 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE343805 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1512717 ncbi.nlm.nih.gov/bioproject/PRJNA1512717 ↗
project · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE343805 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |