Omics · study · 2026
snRNAseq of diffuse leptomeningeal glioneuronal tumors
Listed in NCBI GEO
As part of a larger study on disseminated pediatric low-grade gliomas, we performed scRNAseq on two diffuse leptomeningeal glioneuronal tumors (DLGNT), one of which remained low-grade, and the other of which underwent high-grade transformation.
Description
Using this data, we compared the cellular pathway activation of each tumor, identifying a subpopulation of highly proliferative tumor cells in the transformed sample, which had elevated MAPK pathway activity and depressed p53 pathway activity.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE288nnn/GSE288107 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE288107 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1216204 ncbi.nlm.nih.gov/bioproject/PRJNA1216204 ↗
project · from NCBI GEO
- PubMed 41117845 pubmed.ncbi.nlm.nih.gov/41117845 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE288107 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |