Omics · study · 2026
Mutant KRAS-Driven Selective mRNA Translation Reveals Mechanisms and Therapeutic Vulnerabilities in Cancer
Listed in NCBI GEO
mRNA translation is highly regulated and rapidly controls the functional proteome in response to physiological cues in health and disease.
Description
Mutant KRAS signals to ERKs intersect with the mTOR and EIF4E-EIF4F complex, thereby influencing cap-dependent mRNA translation to promote tumorigenesis. With recent clinical advances in KRAS-targeted therapies, it is important to understand the changes in the mRNA translational landscape and its role in cellular adaptations in response to mutant KRAS-targeted therapies.
We discover that mutant KRAS controls the translation of a subset of mRNAs and affects the protein production of the translation apparatus. Interestingly, these specific subsets of mRNAs have short, weakly folded 5’UTRs, or harbor low folding energy consensus RNA sequences. This mutant KRAS-dependent mechanism differs from mTOR and EIF4E-EIF4F regulation, which governs cap-dependent translation of mRNAs with highly structured, GC-rich 5' UTRs or TOP motifs.
Read the rest (1 more)
Our findings clarify the unique and indispensable role of mutant KRAS in regulating mRNA translation, distinctly setting it apart from the mTOR and EIF4E-EIF4A-dependent mechanism. Our findings uncover a novel mechanism by which mutant KRAS selectively uncouples the mRNA translation of the translation machinery from the broader mRNA pool, redefining our understanding of the oncogenic regulation of mRNA translation in cancer.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE285nnn/GSE285857 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE285857 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1206226 ncbi.nlm.nih.gov/bioproject/PRJNA1206226 ↗
project · from NCBI GEO
- PubMed 42284146 pubmed.ncbi.nlm.nih.gov/42284146 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens · Other
- From keywords
- Life Sciences
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE285857 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |