Omics · study · 2026
Transcriptomic Signatures Associated with Brain Metastasis Across Breast Cancer Subtypes
Listed in NCBI GEO
Brain metastasis is a significant complication of breast cancer, and its molecular determinants vary across breast cancer subtypes.
Description
This study examined transcriptomic differences associated with brain metastasis using RNA sequencing of breast cancer tissues. The deposited RNA-seq dataset contains 42 analyzed biological samples, comprising 23 samples classified as brain-metastasis positive and 19 as brain-metastasis negative.
Differential gene-expression and functional enrichment analyses were used to characterize brain-metastasis-associated transcriptional programs across Luminal A, Luminal B, HER2-enriched, and triple-negative breast cancer subtypes.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE345nnn/GSE345865 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE345865 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1522262 ncbi.nlm.nih.gov/bioproject/PRJNA1522262 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE345865 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |