Omics · study · 2026
Prime Editing Enables Isogenic Modeling of PNPLA3-I148M-Associated Lipotoxicity in Hepatocytes
Listed in NCBI GEO
We demonstrate that prime editing enables a precise approach for modeling PNPLA3-I148M in human hepatocytes, offering a platform to investigate genotype-specific cellular responses.
Description
By combining precise genome editing with human cell modeling, this study provides new insight into the biology of a key risk allele and establishes a platform for personalized therapeutic strategies targeting genetically defined subgroups of liver disease.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313544 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313544 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1380303 ncbi.nlm.nih.gov/bioproject/PRJNA1380303 ↗
project · from NCBI GEO
- PubMed 42438834 pubmed.ncbi.nlm.nih.gov/42438834 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE313544 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |