Replication Data for: Mesoporous Silica Nanocarrier-Mediated Delivery of Pt(II)-Ferrocene Conjugates for Enhanced Antitumor Activity and Toxicity Mitigation

Each monocation contains a Pt(II) center bearing two cis-isopropylamine ligands and a p-ferrocenylaniline ligand directly bound to platinum, and the complexes differ only in the counterion (C1, triflate; C2, nitrate). These compounds had been previously synthesized, showing moderate cytotoxic activity against several cancer cell lines after short incubation times, in some cases surpassing cisplatin at high concentrations.

Because MSNs are pharmaceutically relevant nanocarriers that can protect metal complexes, modulate exposure and sustain release, this work examines whether their incorporation into amino-functionalized MSNs enhances in vitro activity at low Pt-equivalent concentrations and prolonged exposure times. MSNs were synthesized, amino-functionalized with APTMS and loaded with the Pt(II)-ferrocene complexes through non-covalent interactions.