Transcriptomic profiling (RNA-seq) of the mid-region heart tissue from wild-type (WT) and TET2KO mice following 28 days of Angiotensin II treatment.

To determine how endothelial-specific deletion of TET2 affects the cardiac microenvironment under stress, we performed total RNA sequencing (RNA-seq) on the mid-ventricular region of the heart harvested from wild-type (WT) and endothelial-specific TET2 knockout (TET2KO) mice after 28 days of Ang II infusion.

This dataset captures the global transcriptomic landscape of the heart, facilitating the identification of gene expression shifts, extracellular matrix remodeling, and hypertrophic markers associated with endothelial TET2 deficiency.