Altered miRNA cargo of endometrial extracellular vesicles in endometriosis: potential implications for pregnancy outcomes

Among which hsa-miR-1290, hsa-miR-1246, hsa-miR-4516, hsa-miR-191-5p, hsa-miR-335-5p, hsa-miR-12136 and hsa-miR-3065-5p had previously been described as related to gestational complications or endometriosis pathogenesis. These miRNAs targeted 3,964 genes and GO enrichment analysis of these miRNA target genes identified 789 biological processes in endometriosis (FDR<0.05) involved in embryo development and developmental growth, immune system function and angiogenesis, which are important for embryo-maternal tolerance and nutrition; and mesenchymal-epithelial and epithelial-mesenchymal transitions, that are crucial for embryo invasion.

KEGG pathway analysis revealed 32 deregulated pathways (FDR<0.05), including PI3K-Akt pathway involved in pathogenesis of preeclampsia.