Replication Code for Time to diagnosis among children and adolescents with cancer in Quebec, Canada: a population-based study

Methods

We conducted a retrospective population-based study of children and adolescents aged 0–19 years diagnosed with one of 12 common cancers between 2010 and 2022 in Quebec, Canada. The diagnostic interval was defined as the time from first cancer-related healthcare encounter to diagnosis. We calculated medians and interquartile ranges (IQR) overall and by cancer type and used multivariable quantile regression to identify factors associated with time to diagnosis at the 25th, 50th, and 75th percentiles.

Results: Among 2,927 individuals with cancer, diagnostic intervals varied by cancer type and age. Median intervals were longest for carcinomas (100 days; IQR 33–192) and shortest for leukemias (8 days; IQR 3–44). Compared with children living in Montréal, living in regional areas and other large urban centres was associated with longer 50th and 75th percentiles of time to diagnosis for hepatic and central nervous system (CNS) tumours.

Diagnostic intervals were shorter in the post-pandemic period (2020–2022) across several cancer sites, with CNS tumours showing reductions across all quantiles. Interpretation: Diagnostic timeliness differed by cancer type, age, and rurality, but not by sex, material, or social deprivation. The shorter diagnostic intervals observed in the post-pandemic period suggest that pandemic-related changes in care pathways may have expedited diagnosis for some cancers.