Omics · study · 2026
p38 delta systemic genetic deletion mitigates anthracycline cardiotoxicity in female mice
Listed in NCBI GEO
Doxorubicin (DOX) is an effective anthracycline chemotherapy, but its clinical use is limited by dose-dependent cardiotoxicity.
Description
We previously found that systemic genetic deletion of the p38δ kinase protects female mice from DOX-induced cardiotoxicity (DIC), suggesting that selective inhibition of this kinase may be a therapeutic strategy. To explore the mechanisms underlying this protection, we performed bulk RNA sequencing to profile transcriptomic changes associated with p38δ deletion during DIC.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE308nnn/GSE308615 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE308615 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1331723 ncbi.nlm.nih.gov/bioproject/PRJNA1331723 ↗
project · from NCBI GEO
- PubMed 41874387 pubmed.ncbi.nlm.nih.gov/41874387 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE308615 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |