Spatial and cell type specific molecular genetic investigations of inflammatory myopathies with selective perifascicular injury [RNA]

Targeted therapy is still lacking. Efficient serum or histological markers to measure disease activity and predict disease course are missing.

Perifascicular myofiber atrophy is a hall mark of dermatomyositis (DM). Despite decades of research, the mechanism of perifascicular atrophy is still incompletely understood. Across other IIM subtypes, perifascicular myofiber necrosis is also the hall mark pathology for antisynthetase syndrome associated myositis (ASyS)5, and can be seen in a subset of lupus myositis (LM).