Excel · study · 2026
High-Dose Vitamin D3 Supplementation Associates with Innate Immune Chromatin Remodeling and Context-Dependent Transcriptomic Responses in Multiple Sclerosis [ATAC-seq]
Listed in NCBI GEO
We performed longitudinal RNA-seq and ATAC-seq profiling of PBMCs from multiple sclerosis patients receiving vitamin D₃ supplementation for day 0 and day 84.
Description
MS samples remained molecularly distinct from controls, with supplementation modulating discrete, context-dependent immune pathways rather than inducing global transcriptomic shifts. Integrated analysis identified candidate vitamin D–responsive regulatory mechanisms with potential relevance to MS pathophysiology.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE320nnn/GSE320191 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE320191 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1427108 ncbi.nlm.nih.gov/bioproject/PRJNA1427108 ↗
project · from NCBI GEO
- PubMed 42601952 pubmed.ncbi.nlm.nih.gov/42601952 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Longitudinal study 65% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE320191 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].local:method:longitudinal-study | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |