Omics · study · 2026
Chromatin Remodeler Znhit1 Controls Angiogenic Programs to Safeguard Retinal and Cerebral Vascular Integrity
Listed in NCBI GEO
Angiogenesis and vascular barrier formation are essential for central nervous system (CNS) development and homeostasis, but the chromatin-based regulation of these processes remains poorly understood.
Description
Here, we identify the chromatin remodeling factor Znhit1 as a critical regulator of endothelial function in the retina and brain. Znhit1 is robustly expressed in retinal endothelial cells during postnatal vascular development.
Endothelial-specific deletion of Znhit1 in mice caused profound vascular defects including impaired angiogenesis, reduced endothelial proliferation, and increased vascular permeability. These defects were accompanied by disrupted Claudin-5 and VE-Cadherin organization and elevated PLVAP expression. In the brain, Znhit1 loss led to reduced vascular density and barrier breakdown.
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Transcriptomic profiling revealed that Znhit1 regulates angiogenesis, migration, and junction assembly pathways, and genomic analyses showed that Znhit1 targets promoters or enhancers of key vascular regulators including Kdr (which encodes VEGFR2), Tek (which encodes Tie2), and Slc7a5. Moreover, Tie2 overexpression attenuated permeability defects in cultured human endothelial cells that lack ZNHIT1. These findings establish Znhit1 as an essential epigenetic regulator of CNS angiogenesis and barrier integrity in the central nervous system and have implications for development of treatments for vascular and neurovascular disease.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE309nnn/GSE309482 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE309482 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1336148 ncbi.nlm.nih.gov/bioproject/PRJNA1336148 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE309482 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |