Omics · study · 2026
RNA-seq of human synovium from patients with osteoarthritis, rheumatoid arthritis, anterior cruciate ligament rupture, and meniscus tear
Listed in NCBI GEO
RNA sequencing (RNA-seq) was performed on human synovial tissues obtained from patients with osteoarthritis (OA), rheumatoid arthritis (RA), anterior cruciate ligament rupture (ACLR), and meniscus tear (MT) to characterize transcriptional programs associated with synovial pathology.
Description
Osteoarthritis is a heterogeneous joint disease exhibiting substantial variability in synovial inflammation, vascularization, and fibrotic remodeling.
In this study, synovial tissue samples were collected from patients undergoing joint surgery, and bulk RNA-seq was conducted to profile gene expression across different disease contexts. These transcriptomic data were generated as part of a broader effort to investigate the molecular basis of synovial tissue heterogeneity and its relationship to histological architecture and disease severity.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327890 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327890 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1452949 ncbi.nlm.nih.gov/bioproject/PRJNA1452949 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE327890 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |