Omics · study · 2026
Therapeutic effect of ANGPTL4 antisense oligonucleotide treatment in pneumonia caused by PAO1 bacteria or PR8 virus
Listed in NCBI GEO
A bacterial pneumonia model represented by Pseudomonas aeruginosa (PAO1) or viral pneumonia model by PR8 virus infection were constructed, and then the drug of antisense oligonucleotide(ASO) for ANGPTL4 is administered for treatment.
Description
The inflammatory status of mouse lung tissue is analyzed pathologically and the inflammatory cell count is carried out to evaluate the therapeutic effect of the drug. Similarly, the expression of ANGPTL4 protein in mice is detected and its corresponding lung tissues are analyzed for transcriptomic analysis, and its possible functional pathways are further explored and summarized.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE288nnn/GSE288259 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE288259 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1216642 ncbi.nlm.nih.gov/bioproject/PRJNA1216642 ↗
project · from NCBI GEO
- PubMed 41869866 pubmed.ncbi.nlm.nih.gov/41869866 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE288259 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |