Omics · study · 2026
A noncanonical function of SCIMP restricts JAK1 activity to counteract immune evasion in bladder cancer
Listed in NCBI GEO
Despite the fact that immunotherapy is reshaping the therapeutic landscape of bladder cancer, immune evasion remains a major obstacle to durable clinical benefit.
Description
In this study, we performed a genome-wide CRISPR-Cas9 screen in bladder cancer cells co-cultured with CD8⁺ T cells and identified SCIMP as a key gene that enhances CD8⁺ T cell antitumor immunity. SCIMP serves as a favorable prognostic biomarker in bladder cancer patients treated with immunotherapy.
Mechanistically, SCIMP inhibits JAK1 phosphorylation in an adaptor-independent manner, suppressing IFN-γ/JAK1/STAT5A/PD-L1 signaling axis. Meanwhile, YTHDF2 destabilizes the m6A tagged SCIMP transcripts. Remarkably, SCIMP synergizes with PD-1 blockade in suppressing tumor growth.
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Collectively, these findings reveal a previously unexplored noncanonical role of SCIMP in preventing immune evasion and provide a potential therapeutic target for bladder cancer.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE320nnn/GSE320572 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE320572 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1423439 ncbi.nlm.nih.gov/bioproject/PRJNA1423439 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE320572 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |