Human iPSC-Derived Cardiac Progenitor Cells Recapitulate Endogenous CPC Function and Offer a Rejuvenated Cell Source for Cardiac Regeneration

Human iPSC-derived CPCs have previously been generated however current strategies are limited by the generation of developmentally immature and heterogeneous progenitor populations with restricted expansion capacity.

A lack of donor-matched comparisons with native human CPCs has also limited insight into their developmental fidelity, functional competence, and translational relevance. Together, this study provides the first comprehensive donor-matched comparison of hiPSC-derived and native CPCs, establishing hiPSC-CPCs as an accessible, standardised, and rejuvenated progenitor source that closely mirrors native CPC identity and function.