Omics · study · 2026
Impact of METTL1 on global gene expression in AML [RNA-Seq]
Listed in NCBI GEO
Methyltransferase 1 (METTL1) is an enzyme responsible for the m7G modification of tRNAs.
Description
Our studies indicated that METTL1 is highly expressed in AML samples and its elevated level predicts poor prognosis of AML patients. Knockout (KO) of METTL1 in AML cells significantly suppressed their growth in vitro, and substantially delayed leukemogenesis in vivo.
Additional rescue assays demonstrated the functions of METTL1 in AML primarily depended on its enzymatic activity. To delineate the molecular mechanism through which METTL1 exerts its biological functions in AML, we conducted transcriptome-wide RNA sequencing with U-937 AML cells following METTL1 KO.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE316nnn/GSE316203 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE316203 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1401800 ncbi.nlm.nih.gov/bioproject/PRJNA1401800 ↗
project · from NCBI GEO
- PubMed 42247311 pubmed.ncbi.nlm.nih.gov/42247311 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE316203 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |