Whole-genome sequencing in B-cell lymphomas for circulating tumor DNA analysis by multiplex digital PCR for disease monitoring

<p>WGS data of paired tumor and normal samples in 9 patients (6 diffuse large B-cell lymphomas, 1 transformed follicular lymphoma and 2 follicular lymphoma) with a median depth of 37X (range: 27-50X). </p> <p>The study was approved by the Stockholm Regional Ethical committee (2017/2538-31) and conducted in accordance with the Declaration of Helsinki. Written informed consent was obtained from the patients. </p> <p>The data consits of BAM-files from whole-genome sequencing (WGS) of diagnostic fresh frozen lymph node biopsies and matching whole blood for germline analysis.

Sequencing was performed on a NovaSeq 6000 system (Illumina) using paired-end 150 bp readout, aiming at 300 M paired reads. Pre-processing of raw FASTQ files and variant calling was performed by Bioinformatic Analysis pipeLine for SomAtic MutatIons in Cancer (BALSAMIC) version 10.0.2.</p> <p><br></p> <p><strong>Data Access Statement</strong></p> <p><br></p> <p>The WGS dataset are only to be used for academic research purposes at advancing the understanding of genetic factors in the pathogenesis of B-cell lymphomas.