Omics · study · 2026
Nociceptive sensory nerves induce an IL4Rαhi anti-inflammatory macrophage subset that protects against kidney ischemia-reperfusion injury [DRG_RNAseq]
Listed in NCBI GEO
Kidney is not a classic pain-sensitive organ but innervated by dense transient receptor potential cation channel subfamily V member 1 (TRPV1+) nociceptive sensory nerves, indicating potential regulatory functions of these nerves beyond pain perception that remains unknown.
Description
Macrophage-mediated inflammation is a critical step in the pathophysiology of AKI. Here, we reveal a neuroimmune axis wherein TRPV1+ nociceptive sensory neurons protect against kidney ischemia-reperfusion (I/R) injury by orchestrating macrophage polarization.
The renal inflammation level is closely monitored by nociceptive sensory nerves. These nerves activate and initiate reparative programs to alleviate I/R injury by releasing calcitonin gene-related peptide (CGRP), which signals through Receptor Activity Modifying Protein 1 (RAMP1)/ Calcitonin Receptor-Like Receptor (CALCRL) receptors on macrophages to induce a unique interleukin 4 receptor alpha (IL-4Rαhi) population via cAMP-PKA-CREB-dependent pathway.
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CGRP synergizes with IL-4 to promote the anti-inflammatory and pro-healing function of macrophages, establishing a feedforward loop for macrophage repolarization. Clinically, elevated urinary CGRP levels correlated with reduced kidney injury markers and higher proportions of anti-inflammatory macrophages in post-nephrectomy patients. Our findings revealed a new role of renal sensory nerves as a critical regulator of renal repair through neuroimmune crosstalk, offering therapeutic opportunities for AKI.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE299nnn/GSE299312 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE299312 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1273895 ncbi.nlm.nih.gov/bioproject/PRJNA1273895 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE299312 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |